Yes, according to IDOH. Its instruction letter for initial applicants says "The personal services agency must have a physical location within the State of Indiana." and "The provider may utilize a home or residential address for the personal services agency." IDOH instruction letter (last updated August 2022), page 3 IDOH’s application form adds that you need a physical location and an operational agency phone. State Form 53391, Section II.A The statute, IC 16-27-4, does not say what kind of premises the office must be, though it assumes an office in Indiana, where records are kept. IC 16-27-4-18
The letter dates from the paper application process, and IDOH’s current program page does not link it (in the copy we saved on October 1, 2026). We found nothing newer from IDOH on home offices. Confirming with PSA@health.IN.gov before you apply is our suggestion. Remember that the practice address is public: IDOH’s directory lists each agency’s street address. IDOH PSA directory
Wherever the office is, records must be kept there, or be electronically accessible there, for at least seven years, and IDOH reads the statute as giving you 24 hours to produce documents it asks for. IC 16-27-4-18 IDOH-HCBC/PSA-1